UCSD Biochemical Genetics Veterinary Diagnostic Services

Quantitative Organic Acid Comprehensive (Urine, Plasma, Cerebrospinal Fluid)

Comments: This analysis is useful in the evaluation of dogs with persistent lactic acidemia and/or lipid storage myopathy. Evaluations are also essential for dogs with unexplainable neurological disorders, failure to thrive, or elevated anion gaps. Our organic acid analysis is based on a state-of-the-art application of gas chromatography-mass spectrometry. Identification of metabolites is definitive, and we fully quantitate more than 150 compounds. Note that other laboratories may give qualitative results only or report results without mass spectral identification, which can lead to serious misinterpretation.

Sample requirements: Urine, 10-20 mL (minimum 5 mL), frozen without preservatives and shipped frozen (packed with dry ice) or lyophilized and shipped at room temp with original volume specified. Plasma, ³2 mL (minimum 1.0 mL) from heparinized blood (green top tube) supernatant from clinical centrifugation (within 20 minutes) promptly frozen and shipped frozen (packed with dry ice) or lyophilized and shipped at room temperature with original volume specified. Cerebrospinal fluid, ³2 mL (minimum 1.0 mL)[standard plastic LP tube or transferred to red top tube], frozen and shipped frozen (packed with dry ice).

Turn-around time: Routine: 10-14 working days

 

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